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Zanaflex (Tizanidine-Oral (tize-AN-ih-deen))

Drug Class and Mechanism Zanaflex
Tizanidine is an agonist at (alpha) 2 -adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, tizanidine has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of tizanidine are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons.The imidazoline chemical structure of tizanidine is related to that of the anti-hypertensive drug clonidine and other (alpha) 2 -adrenergic agonists. Pharmacological studies in animals show similarities between the two compounds, but tizanidine was found to have one-tenth to one-fiftieth (1/50) of the potency of clonidine in lowering blood pressure.

Drug Uses Zanaflex
Zanaflex (Tizanidine-Oral) is a muscle relaxant is used to help relax certain muscles in your body.

Learn more about Zanaflex here
* If you experience any of the following serious side effects, stop taking tizanidine and seek emergency medical attention:* an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);* hallucinations or abnormal behavior; or* liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue).* Other, less serious side effects may be more likely to occur. Continue to take tizanidine and talk to your doctor if you experience* drowsiness or dizziness;* weakness;* dry mouth;* increased muscle tone or spasms; or* sweating.* Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

How Taken Zanaflex
Zanaflex comes as a tablet to take it orally. It usually is taken two or three times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Zanaflex exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

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